Marinomed Biotech AG: Marinomed Biotech AG publishes clinical data on efficacy of Carragelose lozenges against respiratory viruses including SARS-CoV-2 in the International Journal of General Medicine
DGAP-News: Marinomed Biotech AG
/ Key word(s): Scientific publication
Marinomed Biotech AG publishes clinical data on efficacy of Carragelose lozenges against respiratory viruses including SARS-CoV-2 in the International Journal of General Medicine
Korneuburg, Austria, 09 September 2021 – Marinomed Biotech AG (VSE:MARI), an Austrian science-based biotech company with globally marketed therapeutics derived from innovative proprietary technology platforms, announced today that positive clinical data on the antiviral efficacy of Carragelose-containing lozenges have been published in the peer-reviewed journal International Journal of General Medicine. The open access paper can be accessed on the journal’s website: https://www.dovepress.com/articles.php?article_id=68558. The study was conducted in collaboration with Prof. Ulrich Schubert, Chair for Clinical Virology at the Friedrich-Alexander University Erlangen-Nuremberg, Germany and his team and adds to the increasing amount of evidence showing effective inhibition of SARS-CoV-2 by Carragelose.
The clinical study investigated whether sucking of one Carragelose-containing (10 mg) lozenge would lead to sufficient iota-carrageenan concentrations in the saliva of 31 healthy subjects to neutralize seven human respiratory viruses that cause common colds as well as COVID-19. The resulting iota-carrageenan concentrations are many times higher than the concentrations needed to inhibit 90 % of viral replication (IC90) of all tested viruses. This indicates that the lozenges are an appropriate measure to reduce infection and potentially preventing severe illness as well as transmission within a population.
Specifically, the scientific paper shows that the sucking of one lozenge led to a Carragelose-concentration in saliva above the concentration required to inhibit 90 % of viral particles (IC90) for human Rhinovirus (HRV) 1a and 8, surpassing the previously published IC90 values of 5 μg / ml for neutralization by more than a hundredfold (p < 0.001). The saliva obtained from study participants also showed significant antiviral efficacy against Coronavirus OC43, Influenza A nH1N1 2009, Coxsackie virus A10, and human Parainfluenza Virus Type 3 (p < 0.001 for all viruses).
SARS-CoV-2 could also be effectively inhibited by saliva obtained after consumption of one Carragelose lozenge. An analysis performed by Prof. Dr. Ulrich Schubert’s group at the Friedrich Alexander University of Erlangen-Nuremberg, Germany showed that saliva contained more than 100 times the amount of Carragelose necessary to inhibit SARS-CoV-2 in antiviral efficacy tests.
“Carragelose is broadly active against various respiratory viruses. In this study, we were able to demonstrate that after consuming one lozenge, the Carragelose concentration contained in saliva is more than 100 times higher than needed to efficiently inhibit SARS-CoV-2 replication in various cell lines. This suggests that the consumption of Carragelose lozenges forms a physical barrier on the mucosa, which traps the viruses based on their positive surface charge. This potentially reduces the viral load in an infected person and ultimately may help to prevent the spread of SARS-CoV-2 among, and ameliorate the disease in, individuals,” said Prof. Dr. Ulrich Schubert, Chair for Clinical Virology at the Friedrich-Alexander University Erlangen-Nuremberg, Germany and Marinomed’s cooperation partner.
“These results further confirm what we have seen in several recent studies, both conducted by us and independently: Carragelose is an effective tool against respiratory viruses, including SARS-CoV-2. We are glad that with the data published here we were able to confirm that Carragelose lozenges release multiple times more active compound than necessary to neutralize all tested viruses,” said Dr. Eva Prieschl-Grassauer, Chief Scientific Officer at Marinomed. “It has become increasingly clear that the current pandemic will not end abruptly, but rather is SARS-CoV-2 here to stay. In light of the emerging variants of concern it will be important to have multiple lines of defence against COVID-19. Carragelose has the potential to act as an additional measure alongside vaccines to help contain the pandemic and to protect people.”
Carragelose lozenges and nasal sprays are available in pharmacies without prescription through Marinomed’s worldwide distributor network. Carragelose has been well established to prevent respiratory infections by various viruses, including certain influenza and endemic Coronaviruses. More recently, Carragelose has been shown to effectively inactivate both wildtype and common variants of the new Coronavirus SARS-CoV-2, including the so-called P1 or gamma variant. Clinical data from an independent study in Argentina had demonstrated an 80 % reduction in PCR-confirmed COVID-19 cases in hospital staff after Carragelose-treatment.,
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